Gold(I)-Catalyzed Oxidative Cascade Cyclization of 1,4-Diyn-3-ones for the Construction of Tropone-Fused Furan Scaffolds

• 山口, 亞由太

  Graduate School of Pharmaceutical Sciences, Kyoto University

• 井貫, 晋輔

  Graduate School of Pharmaceutical Sciences, Kyoto University

• 大石, 真也

  Graduate School of Pharmaceutical Sciences, Kyoto University

• 大野, 浩章

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Ohno, Hiroaki

  Graduate School of Pharmaceutical Sciences, Kyoto University

抄録

Gold(I)-catalyzed cascade cyclization of 1, 4-diyn-3-ones with a pyridine N-oxide enabled direct construction of a benzo[6, 7]cyclohepta[1, 2-b]furan scaffold with the formation of four bonds. This reaction would proceed through oxidative cyclization, alkynyl migration, and 5-endo-dig type cyclization. Synthesis of benzotropone-fused naphtho[1, 2-b]furans through a two-step sequence, including epoxidation and In(OTf)₃-catalyzed intramolecular carbon–carbon bond formation, is also presented.

収録刊行物

• Organic Letters

  Organic Letters 20 (15), 4401-4405, 2018-08-03

  American Chemical Society

詳細情報

• CRID: 1050001202930192512
• NII論文ID: 120006634623
• ISSN: 15237060
• ISSN: 15237052
• HANDLE: 2433/241630
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles