Total Synthesis of (+)-Conolidine by the Gold(I)-Catalyzed Cascade Cyclization of a Conjugated Enyne

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Abstract

A total synthesis of (+)-conolidine has been achieved via the gold(I)-catalyzed cascade cyclization of a conjugated enyne. Remarkably, this strategy allowed for the simultaneous formation of the indole ring and the ethylidene-substituted piperidine moiety of (+)-conolidine under homogeneous gold catalysis in an enantioselective manner (88–91% ee).

Journal

  • The Journal of Organic Chemistry

    The Journal of Organic Chemistry 81(13), 5690-5698, 2016-07

    American Chemical Society (ACS)

Codes

  • NII Article ID (NAID)
    120006634624
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0022-3263
  • Data Source
    IR 
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