Biocompatible nanostructured solid adhesives for biological soft tissues

• Okada, Masahiro

• Nakai, Akira

• Hara Emilio, Satoshi

• Taguchi, Tetsushi

• Nakano, Takayoshi

• Matsumoto, Takuya

抄録

Over the past few years, the development of novel adhesives for biological soft tissue adhesion has gained significant interest. Such adhesives should be non-toxic and biocompatible. In this study, we synthesized a novel solid adhesive using nanostructured hydroxyapatite (HAp) and evaluated its physical adhesion properties through in vitro testing with synthetic hydrogels and mouse soft tissues. The results revealed that HAp-nanoparticle dispersions and HAp-nanoparticle-assembled nanoporous plates showed efficient adhesion to hydrogels. Interestingly, the HAp plates showed different adhesive properties depending upon the shape of their nanoparticles. The HAp plate made up of 17 nm-sized nanoparticles showed an adhesive strength 2.2 times higher than that of the conventional fibrin glue for mouse skin tissues.

収録刊行物

• Acta Biomaterialia

  Acta Biomaterialia 57 404-413, 2017-05

  Elsevier B.V.

キーワード

• Hydroxyapatite
• Nanoparticle
• Solid adhesive
• Wet adhesion

詳細情報

• CRID: 1050001202936116224
• NII論文ID: 120006635193
• NII書誌ID: AA12033647
• ISSN: 17427061
• Web Site: https://ousar.lib.okayama-u.ac.jp/55197
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles