Green Tea Ameliorates Hyperglycemia by Promoting the Translocation of Glucose Transporter 4 in the Skeletal Muscle of Diabetic Rodents

• Ueda-Wakagi, Manabu

• Nagayasu, Hironobu

• 山下, 陽子

• 芦田, 均

抄録

It is known that green tea helps prevent obesity and diabetes mellitus. In this study, we aimed to determine whether green tea ameliorates hyperglycemia and the mechanism involved in diabetic rodents. Green tea consumption reduced blood glucose and ameliorated glucose intolerance, which was assessed using an oral glucose tolerance test in both streptozotocin-induced type 1 diabetic rats and type 2 diabetic KK-A(y) mice. Green tea also reduced the plasma fructosamine and glycated hemoglobin concentrations in both models. Furthermore, it increased glucose uptake into the skeletal muscle of both model animals, which was accompanied by greater translocation of glucose transporter 4 (GLUT4). Moreover, epigallocatechin gallate (EGCG), the principal catechin in green tea, also ameliorated glucose intolerance in high-fat diet-induced obese and diabetic mice. These results suggest that green tea can ameliorate hyperglycemia in diabetic rodents by stimulating GLUT4-mediated glucose uptake in skeletal muscle, and that EGCG is one of the effective compounds that mediate this effect.

収録刊行物

• International Journal of Molecular Sciences

  International Journal of Molecular Sciences 20 (10), 2436-2436, 2019-05

  MDPI

キーワード

• green tea
• diabetes
• skeletal muscle
• glucose transporter 4

詳細情報

• CRID: 1050575520346494592
• NII論文ID: 120006649615
• ISSN: 14220067
• ISSN: 16616596
• HANDLE: 20.500.14094/90006141
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles