Challenges in developing mucosal vaccines and antibodies against infectious diarrhea in children

• Tokuhara, Daisuke

Abstract

Infectious diarrhea in children can be life-threatening and imposes a large economic burden on healthcare systems, therefore more effective prophylactic and therapeutic drugs are needed urgently. Because most of the pathogens responsible for childhood diarrhea infect the gastrointestinal mucosa, providing protective immunity at the mucosal surface is an ideal way to control pathogen invasion and toxic activity. Mucosal (e.g., oral, nasal) vaccines are superior to systemic (subcutaneous or intramuscular) vaccination for conferring both mucosal and systemic pathogen-specific immune responses, and for the past 50 years, great efforts has been focused on the development of cost-effective mucosal vaccines....

Journal

• Pediatrics International

  Pediatrics International 60 (3), 214-223, 2018-03

  Wiley

Keywords

• ロタウイルス
• コレラ菌
• antibody fragment
• mucosal immunity
• rice-based vaccine
• rotavirus
• Vibrio cholerae

Details

• CRID: 1050846638309656960
• NII Article ID: 120006652520
• NII Book ID: AA11631585
• ISSN: 1442200X
• ISSN: 13288067
• DOI: 10.1111/ped.13497
• Web Site: https://dlisv03.media.osaka-cu.ac.jp/il/meta_pub/G0000438repository_1442200X-60-3-214
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fped.13497
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1111/ped.13497
• Web Site: https://search.jamas.or.jp/link/ui/2019115394
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN