Catalytic Asymmetric Synthesis of <i>anti</i>-α,β-Diamino Acid Derivatives

• 泉, 早苗

  Graduate School of Pharmaceutical Sciences, Kyoto University

• 小林, 祐輔

  Graduate School of Pharmaceutical Sciences, Kyoto University

• 竹本, 佳司

  Graduate School of Pharmaceutical Sciences, Kyoto University

書誌事項

タイトル別名

• Catalytic Asymmetric Synthesis of anti-α,β-Diamino Acid Derivatives

抄録

A novel approach to chiral anti-α, β-diamino acid derivatives through tandem orthogonal organocatalysis has been developed. Chiral phosphoric acid catalysts control the chemo-, regio-, and stereoselective addition of hydroxylamines to alkylideneoxazolones, while a phosphine catalyst promotes the isomerization of Z- alkylideneoxazolones to the more reactive E- alkylideneoxazolones. (Chemical Equation Presented).

収録刊行物

• Organic Letters

  Organic Letters 18 (4), 696-699, 2016-02-19

  American Chemical Society (ACS)

キーワード

• Organic Chemistry
• Physical and Theoretical Chemistry
• Biochemistry

詳細情報

• CRID: 1050282813364796800
• NII論文ID: 120006653020
• ISSN: 15237052
• ISSN: 15237060
• DOI: 10.1021/acs.orglett.5b03666
• HANDLE: 2433/242996
• Web Site: https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.5b03666
• 本文言語コード: en
• 資料種別: journal article
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