Enantioselective Synthesis of anti-β-Hydroxy-α-amino Esters via an Organocatalyzed Decarboxylative Aldol Reaction

• 竹本, 佳司

  Graduate School of Pharmaceutical Sciences, Kyoto University

• 小林, 祐輔

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Murata, Akihiro

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Kobayashi, Yusuke

  Graduate School of Pharmaceutical Sciences, Kyoto University

抄録

The first enantioselective decarboxylative aldol addition with α-amido-substituted malonic acid half oxyesters (MAHOs) is described. The combined use of a newly designed bifunctional sulfonamide catalyst with pentafluorobenzoic acid as an additive afforded the β-hydroxy-α-amino acid derivatives in moderate to high yields and with high enantioselectivities.

収録刊行物

• Synlett

  Synlett 28 (11), 1295-1299, 2017-07

  Georg Thieme Verlag

キーワード

• bifunctional organocatalyst
• cinchona alkaloid
• malonic acid half oxyester (MAHO)
• sulfonamide
• β-hydroxy-α-amino acid

詳細情報

• CRID: 1050564288341529856
• NII論文ID: 120006653111
• ISSN: 09365214
• ISSN: 14372096
• DOI: 10.1055/s-0036-1588141
• HANDLE: 2433/243148
• Web Site: http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0036-1588141.pdf
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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  • Crossref
  • CiNii Articles
  • KAKEN