Sendai Virus V Protein Inhibits the Secretion of Interleukin-1β by Preventing NLRP3 Inflammasome Assembly

DOI Web Site 被引用文献2件 参考文献42件
  • Takayuki Komatsu
    Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Aichi, Japan
  • Yukie Tanaka
    Department of Molecular Biology and Chemistry, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
  • Yoshinori Kitagawa
    Division of Microbiology and Infectious Diseases, Department of Pathology, Shiga University of Medical Science, Shiga, Japan
  • Naoki Koide
    Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Aichi, Japan
  • Yoshikazu Naiki
    Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Aichi, Japan
  • Naoko Morita
    Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Aichi, Japan
  • Bin Gotoh
    Division of Microbiology and Infectious Diseases, Department of Pathology, Shiga University of Medical Science, Shiga, Japan
  • Takashi Yokochi
    Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Aichi, Japan
  • Adolfo García-Sastre
    editor

抄録

<jats:p>The present study demonstrates that the V protein of SeV, Nipah virus, and human parainfluenza virus type 2 interacts with NLRP3 to inhibit NLRP3 inflammasome activation, potentially suggesting a novel strategy by which viruses evade the host innate immune response. As all members of the<jats:named-content content-type="genus-species">Paramyxovirinae</jats:named-content>subfamily carry similar V genes, this new finding may also lead to identification of novel therapeutic targets for paramyxovirus infection and related diseases.</jats:p>

収録刊行物

  • Journal of Virology

    Journal of Virology 92 (19), 1-, 2018-10

    American Society for Microbiology

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