The Roles of Coinhibitory Receptors in Pathogenesis of Human Retroviral Infections

機関リポジトリ

抄録

type:論文(Article)

Costimulatory and coinhibitory receptors play a key role in regulating immune responsesto infection and cancer. Coinhibitory receptors include programmed cell death 1 (PD-1),cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), and T cell immunoglobulin andITIM domain (TIGIT), which suppress immune responses. Coinhibitory receptors arehighly expressed on exhausted virus-specific T cells, indicating that viruses evadehost immune responses through enhanced expression of these molecules. Humanretroviruses, human immunodeficiency virus (HIV) and human T-cell leukemia virus type1 (HTLV-1), infect T cells, macrophages and dendritic cells. Therefore, one needs toconsider the effects of coinhibitory receptors on both uninfected effector T cells andinfected target cells. Coinhibitory receptors are implicated not only in the suppression ofimmune responses to viruses by inhibition of effector T cells, but also in the persistenceof infected cells in vivo. Here we review recent studies on coinhibitory receptors and theirroles in retroviral infections such as HIV and HTLV-1.

identifier:https://www.frontiersin.org/articles/10.3389/fimmu.2018.02755/full

収録刊行物

キーワード

詳細情報 詳細情報について

  • CRID
    1050282812911124224
  • NII論文ID
    120006697283
  • ISSN
    16643224
  • Web Site
    http://hdl.handle.net/2298/41363
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • IRDB
    • CiNii Articles

問題の指摘

ページトップへ