Cardiac Complications in Immune Checkpoint Inhibition Therapy

Access this Article

Abstract

Immune checkpoint inhibitors (ICIs) have changed the treatment landscape of advanced cancers. Unfortunately, these agents can induce a wide spectrum of immune-related adverse events (irAEs) through activation of immune responses in non-target organs, including the heart. As the clinical use of ICI therapy increases rapidly, management of irAEs is becoming extremely important. The most commonly presented cardiac irAE is myocarditis. Histopathologically, T-cell (with a predominance of CD8+ cells) and macrophage infiltration in the myocardium is typically observed in ICI-associated myocarditis. Other presentations of cardiac irAEs include congestive heart failure, Takotsubo cardiomyopathy, pericardial disease, arrhythmias, and conduction disease. Although cardiac irAEs are relatively rare, they can be life-threatening. Hence, cardiologists and oncologists should be vigilant for these presentations.

Journal

  • Frontiers in Cardiovascular Medicine

    Frontiers in Cardiovascular Medicine (6), 3, 2019-01

    Frontiers Media

Keywords

Codes

  • NII Article ID (NAID)
    120006708500
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    2297-055X
  • Data Source
    IR 
Page Top