B-cell lymphoma showing typical features of angioimmunoblastic T-cell lymphoma

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  • Ｂ細胞起源と診断した血管免疫芽球性リンパ腫

Abstract

We present a 52-year-old man who was diagnosed with B cell-derived angioimmunoblastic lymphoma. He was admitted with systemic, including mediastinal and para-aortic, lymphadenopathy, fever and skin itching. Histologically, his lymph nodes showed total obliteration of the normal architecture by a polymorphic infiltrate of large-sized lymphocytes with proliferation of arborizing small blood vessels. In addition, hematological examinations showed biclonal hypergammaglobulinemia, leukocytosis with lymphoblasts and bone marrow involvement of these cells. He was clinicopathologically diagnosd with angioimmunoblastic T-cell lymphoma, but cell surface marker analysis and immunoglobulin heavy chain clonal rearrangement demonstrated that lymphoblasts were derived from B lymphocytes. These findings were suggestive of a B cell origin of the lymphoma cells, therefore, we ultimately diagnosed the disease as a B-cell lymphoma showing typical features of angioimmunoblastic T-cell lymphoma. He has not followed the progressive disease, thus we consider that it will be treated as CD20-positive indolent B-cell lymphoma.

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