温度変化による心筋細胞集団の拍動周期変化への影響

• 王 瑋

書誌事項

タイトル別名

• BEATING RATE CHANGES OF CARDIOMYOCYTE CLUSTERS BY ENVIRONMENTAL THERMAL CHANGES

抄録

type:Article

Heart rate is known to slow down or speed up depending on the environmental temperature. To clarify the size dependency of cardiomyocyte clusters, I made different-sized populations of cardiomyocytes and measured the inter spike interval (ISI) at two environmental temperatures (room temperature and living body temperature). My findings show regardless of the size of cluster, the changes of ISI tend to be the same. Heart rate slowed down at room temperature, and returned to the original pace while rewarming to living body temperature. I also found the first peak negative amplitude decreased at room temperature, and returned to the base line at living body temperature. Then I used E-4031 as a Kv11.1 channel blocker to clarify the related ion channels of temperature effects. As a result, ISI decreased at living body temperature and room temperature compared with control. The results of this study demonstrate that cardiomyocyte clusters can sense and respond to temperature changes regardless of the size, and Kv11.1 channel plays an important role in temperature effect of cardiomyocyte.

収録刊行物

• 法政大学大学院紀要. 理工学・工学研究科編

  法政大学大学院紀要. 理工学・工学研究科編 60 1-2, 2019-03-31

  法政大学大学院理工学研究科

キーワード

• temperature effect
• size dependency
• E-4031
• cardiomyocyte cluster

詳細情報

• CRID: 1390572174778399104
• NII論文ID: 120006715077
• NII書誌ID: AA12677220
• ISSN: 21879923
• DOI: 10.15002/00022101
• Web Site: http://hdl.handle.net/10114/00022101
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • IRDB
  • CiNii Articles