Selective Enhancing Effect of Early Mitotic Inhibitor 1 (Emi1) Depletion on the Sensitivity of Doxorubicin or X-ray Treatment in Human Cancer Cells

• Shimizu, Natsumi

• Izumi Nakajima, Nakako

• Tsunematsu, Takaaki

• Ogawa, Ikuko

• Kawai, Hidehiko

• Hirayama, Ryoichi

• Fujimori, Akira

• Yamada, Akiko

• Okayasu, Ryuichi

• Ishimaru, Naozumi

• Takata, Takashi

• Kudo, Yasusei

Bibliographic Information

Other Title

• Selective Effects of Emi1 Depletion in Cancer

Abstract

Background: To improve the effectiveness of chemo- and radiotherapy only in cancer tissue is important for avoiding side effects. Results: Emi1 depletion enhanced the sensitivity of anticancer reagents and X-ray irradiation in cancer cells. Conclusion: Emi1 siRNA would be a useful new modality for enhancing the effect of chemo- and radiotherapy in various tumors. Significance: This work provides new insights regarding synergistic effect of Emi1 knockdown in combination therapies.

Journal

• Journal of Biological Chemistry

  Journal of Biological Chemistry 288 (24), 17238-17252, 2013-05-03

  The American Society for Biochemistry and Molecular Biology

Details

• CRID: 1050845763403125632
• NII Article ID: 120006718350
• NII Book ID: AA1202441X
• ISSN: 1083351X
• Web Site: http://repo.lib.tokushima-u.ac.jp/113579
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles