Roles of Prion Protein in Virus Infections

• Sakaguchi, Suehiro

• Chida, Junji

Bibliographic Information

Other Title

• Prion protein in virus infections

Abstract

The normal cellular prion protein, designated PrPC, is a membrane glycoprotein expressed most abundantly in brains, particularly by neurons, and to a lesser extent in non-neuronal tissues including lungs. Conformational conversion of PrPC into the amyloidogenic isoform is a key pathogenic event in prion diseases. We recently found that PrPC has a protective role against infection with influenza A viruses (IAVs) in mice by reducing reactive oxygen species in the lungs after infection with IAVs. The anti-oxidative activity of PrPC is probably attributable to its function to activate anti-oxidative enzyme Cu/Zn-superoxide dismutase, or SOD1, through regulating Cu content in lungs infected with IAVs. Oxidative stress could play a pivotal role in the pathogenesis of a wide range of viral infections. Here, we introduce our and others’ studies on the role of PrPC in viral infections, and raise the attractive possibility that PrPC might be a novel target molecule for development of anti-oxidative therapeutics against not only IAV infection but also other viral infections.

Journal

• DNA and Cell Biology

  DNA and Cell Biology 37 (10), 808-811, 2018-10-04

  Mary Ann Liebert, Inc.

Keywords

• prion protein
• oxidative stress
• influenza A virus
• superoxide dismutase
• copper
• reactive oxygen species

Details

• CRID: 1050564288739342976
• NII Article ID: 120006731765
• NII Book ID: AA10747642
• ISSN: 10445498
• ISSN: 15577430
• DOI: 10.1089/dna.2018.4402
• Web Site: http://repo.lib.tokushima-u.ac.jp/112207
• Web Site: https://www.liebertpub.com/doi/full-xml/10.1089/dna.2018.4402
• Web Site: https://www.liebertpub.com/doi/pdf/10.1089/dna.2018.4402
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN