Cyclic perylene diimide: Selective ligand for tetraplex DNA binding over double stranded DNA

• Vasimalla, Suresh

• 佐藤, しのぶ

• Takenaka, Fuminori

• Kurose, Yui

• 竹中, 繁織

抄録

Synthesized cyclic perylene diimide, cPDI, showed the binding constant of 6.3 × 106 M−1 with binding number of n = 2 with TA-core as a tetraplex DNA in 50 mM Tris-HCl buffer (pH = 7.4) containing 100 mM KCl using Schatchard analysis and showed a higher preference for tetraplex DNA than for double stranded DNA with over 103 times. CD spectra showed that TA-core induced its antiparallel conformation upon addition of cPDI in the absence or presence of K+ or Na+ ions. The cPDI inhibits the telomerase activity with IC50 of 0.3 µM using TRAP assay which is potential anti-cancer drug with low side effect.

収録刊行物

• Bioorganic & Medicinal Chemistry

  Bioorganic & Medicinal Chemistry 25 (24), 6404-6411, 2017-10-21

  Elsevier

キーワード

• Cyclic perylene diimide
• Tetraplex specific ligand
• Human telomere DNA
• Antiparallel tetraplex DNA
• Inhibition of telomerase activity

詳細情報

• CRID: 1050564288893437824
• NII論文ID: 120006733078
• ISSN: 09680896
• DOI: 10.1016/j.bmc.2017.10.014
• HANDLE: 10228/00007414
• Web Site: https://kyutech.repo.nii.ac.jp/records/6204
• Web Site: https://api.elsevier.com/content/article/PII:S0968089617316772?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0968089617316772?httpAccept=text/plain
• 本文言語コード: en
• 資料種別: journal article
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