Cardioprotective effects of recombinant human erythropoietin in rats with Experimental autoimmune myocarditis

• Mitsuma, Wataru

• Ito, Masahiro

• Kodama, Makoto

• Fuse, Koichi

• Okamura, Kazuki

• Minagawa, Shiro

• Kato, Kiminori

• Hanawa, Haruo

• Toba, Ken

• Nakazawa, Mikio

• Aizawa, Yoshifusa

抄録

Erythropoietin (EPO) has been known to have cytoprotective effects on several types of tissues, presumably through modulation of apoptosis and inflammation. The effect of EPO on myocardial inflammation, however, has not yet been clarified. We investigated the cardioprotective effects of EPO in rats with experimental autoimmune myocarditis (EAM). Seven-week-old Lewis rats immunized with cardiac myosin were treated either with EPO or vehicle and were examined on day22. EPO attenuated the functional and histological severity of EAM along with suppression of mRNAs of tumor necrosis factor (TNF)-a and interleukin (IL)-6 in the hearts as well as a reduction of apoptotic cardiomyocytes. The EPO receptor (EPO-R) was upregulated in the myocardium of EAM compared with that of healthy rats. These results may suggest that EPO ameliorated the progression of EAM by modulating myocardial inflammation and apoptosis.

収録刊行物

• Biochemical and Biophysical Research Communications

  Biochemical and Biophysical Research Communications 344 (3), 987-994, 2006-03

  Elsevier

キーワード

• Erythropoietin
• Experimental autoimmune myocarditis
• Erythropoietin receptor
• Apoptosis

詳細情報

• CRID: 1050564289180135936
• NII論文ID: 120006735347
• NII書誌ID: AA00564395
• ISSN: 0006291X
• HANDLE: 10191/1165
• Web Site: https://niigata-u.repo.nii.ac.jp/records/1554
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles