A Unique and Simple Preparative Method for α-Arylpipecolinic Acid Esters via Base-induced Sommelet-Hauser Rearrangement

• Tayama, Eiji

• Sato, Ryota

• Ito, Motoshi

• Iwamoto, Hajime

• Hasegawa, Eietsu

Abstract

A unique and simple preparative method for N-cyano--aryl pipecolinic acid esters via base-induced Sommelet–Hauser rearrangement, the von Broun reaction, and intramolecular -alkylation is reported. The removal of the N-cyano substituent was achieved by hydrogenation and hydride reduction.

Journal

• Heterocycles

  Heterocycles 87 (2), 381-388, 2013-01

  Elsevier

Keywords

• Organic Chemistry
• Pharmacology
• Analytical Chemistry

Details

• CRID: 1050564289196818560
• NII Article ID: 120006748858
• NII Book ID: AA00663739
• ISSN: 03855414
• DOI: 10.3987/com-12-12619
• HANDLE: 10191/30436
• NDL BIB ID: 024226370
• Web Site: https://niigata-u.repo.nii.ac.jp/records/1693
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024226370
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN