Exercise-Induced Platelet Shape Change and Its Suppression by Trapidil in Normal Subjects

• Hattori, Akira

• Nagai, Tsuneo

• Izumi, Tohru

• Kojima, Tomoko

• Nagayama, Reizo

• Kimura, Michio

• Ojima, Kenji

• Hanano, Masaharu

• Mito, Masao

• Shibata, Akira

抄録

Most results on platelet activation during exercise in normal subjects and patients have recently been criticized as artificial activation ex vivo. The present study examined the shape changes of circulating platelets together with some other parameters in healthy subjects during a bicycle ergometer exercise. Striking shape changes revealed were spherification (decrease in the discoidness index) and pseudopod formation (increase in population of platelets with pseudopods). These changes in platelet shape persisted for 30 min after the exercise and after haemodynamic parameters returned to the pre-exercise level. The changes in the discoidness index and pseudopod formation during the exercise were found to be identical with our previous findings on platelets activated in vitro by ADP or thrombin. Trapidil (600 mg daily for 2 weeks per os), a modulator of platelets activity and vascular functions, significantly suppressed the shape change, suggesting a possible clinical benefit.

収録刊行物

• Acta medica et biologica

  Acta medica et biologica 38 (1), 9-17, 1990-03

  Niigata University School of Medicine

詳細情報

• CRID: 1050001339244882432
• NII論文ID: 120006750350
• NII書誌ID: AA00508361
• ISSN: 05677734
• HANDLE: 10191/33472
• Web Site: https://niigata-u.repo.nii.ac.jp/records/6633
• 本文言語コード: en
• 資料種別: departmental bulletin paper
• データソース種別:
  • IRDB
  • CiNii Articles