5) Post-pregnancy osteoporosisの一症例(シンポジウム 各科領域での代謝性骨疾患, 第439回新潟医学会)

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  • A Case of Post-pregnancy Osteoporosis(Metabolic Bone Disease in Vanious Fields of Medicine)

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Post-pregnancy osteoporosis is a rare but important clinical problem. It is not known whether the association is accidental or causal. During pregnancy, there is an increased need for calcium, both to calcify the fetal bones and perhaps to increase the maternal skeletal mass in preparation for the calcium demands of lactation. This need is normally met by enhanced intestinal calcium absorption brought about by increased 1,25 (OH)_2D_3 production. A concurrent increase in calcitonin secretion prevents unwanted bone resorption. Osteoporosis might develop should there be a failure of calcium accretion by the maternal skeleton. Back pain and vertebral collapse are the most frequent features. Osteoporosis and vertebral compression is not necessarilly worsened, or does not recur, in subsequent pregnancies in the same individual. This helps to answer questions from affected patients about the outcome of future pregnancies, and may also suggest that osteoporosis is related to factors associated with a specific pregnancy.

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