A chimeric mutant analysis in yeast cells suggests BiP independent regulation of the mammalian endoplasmic reticulum-stress sensor IRE1α

• Mai, Thanh Chi

• Munakata, Takeo

• Tran, Duc Minh

• Takagi, Hiroshi

• Kimata, Yukio

抄録

An endoplasmic reticulum (ER)-located transmembrane protein, Ire1, triggers cytoprotective events upon ER stress. Chimeric yeast Ire1 carrying the luminal domain of the mammalian major Ire1 paralogue IRE1α is upregulated in ER-stressed yeast cells, but is poorly associated with the ER-located chaperone BiP even under non-stressed conditions. This observation contradicts the theory that BiP is the master regulator of IRE1α.

収録刊行物

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 82 (9), 1527-1530, 2018-05-28

  公益社団法人日本農芸化学会

キーワード

• unfolded protein response
• molecular chaperone
• stress response
• stress sensing
• organelle

詳細情報

• CRID: 1050014359399339776
• NII論文ID: 120006763863
• ISSN: 13476947
• ISSN: 09168451
• DOI: 10.1080/09168451.2018.1478716
• HANDLE: 10061/13409
• Web Site: https://naist.repo.nii.ac.jp/records/9248
• Web Site: http://academic.oup.com/bbb/article-pdf/82/9/1527/36831144/bbb1527.pdf
• Web Site: https://search.jamas.or.jp/link/ui/2019149494
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN