Categorization of endoplasmic reticulum stress as accumulation of unfolded proteins or membrane lipid aberrancy using yeast Ire1 mutants

• Duc, Minh Tran

• Takagi, Hiroshi

• Kimata, Yukio

抄録

Endoplasmic reticulum (ER)-located protein Ire1 triggers the unfolded protein response against ER-stressing stimuli, which are categorized as ER accumulation of unfolded proteins or membrane lipid-related aberrancy. Here we demonstrate that by using yeast Ire1 mutants, we can distinguish the category to which a stress-inducing stimulus belongs. For instance, ethanol was found to activate Ire1 through both types of cellular damage

収録刊行物

• Bioscience, Biotechnology, and Biochemistry

  Bioscience, Biotechnology, and Biochemistry 83 (2), 326-329, 2018-10-13

  公益社団法人日本農芸化学会

キーワード

• Endoplasmic reticulum
• UPR
• stress response
• yeast
• membrane lipid

詳細情報

• CRID: 1050858784329470336
• NII論文ID: 120006763866
• ISSN: 13476947
• ISSN: 09168451
• DOI: 10.1080/09168451.2018.1530098
• HANDLE: 10061/13406
• Web Site: https://naist.repo.nii.ac.jp/records/9245
• Web Site: http://academic.oup.com/bbb/article-pdf/83/2/326/36833917/bbb0326.pdf
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN