Myo-inositol concentration in MR spectroscopy for differentiating high grade glioma from primary central nervous system lymphoma.

• Nagashima, Hiroaki

• Sasayama, Takashi

• Tanaka, Kazuhiro

• Kyotani, Katsusuke

• Sato, Naoko

• Maeyama, Masahiro

• Kohta, Masaaki

• Sakata, Junichi

• Yamamoto, Yusuke

• Hosoda, Kohkichi

• Itoh, Tomoo

• Sasaki, Ryohei

• Kohmura, Eiji

抄録

It is sometimes difficult to distinguish gliomas from other tumors on routine imaging. In this study, we assessed whether 3-T magnetic resonance spectroscopy (MRS) with LCModel software might be useful for discriminating glioma from other brain tumors, such as primary central nervous system lymphomas (PCNSLs) and metastatic tumors. A total of 104 cases of brain tumor (66 gliomas, 20 PCNSLs, 6 metastatic tumors, 12 other tumors) were preoperatively investigated with short echo time (35 ms) single-voxel 3-T MRS. LCModel software was used to evaluate differences in the absolute concentrations of choline, N-acetylaspartate, N-acetylaspartylglutamate, glutamate + glutamine, myo-inositol (mIns), and lipid. mIns levels were significantly increased in high-grade glioma (HGG) compared with PCNSL (p < 0.001). In multivariate logistic regression analysis, mIns was the best marker for differentiating HGG from PCNSL (p < 0.0001, odds ratio 1.9927, 95% confidence interval 1.3628–3.2637). Conventional MRS detection of mIns resulted in a high diagnostic accuracy (sensitivity, 64%; specificity, 90%; area under the receiver operator curve, 0.80) for HGG. The expression of inositol 3-phosphate synthase (ISYNA1) was significantly higher in gliomas than in PCNSLs (p < 0.05), suggesting that the increased level of mIns in glioma is due to high expression of ISYNA1, the rate-limiting enzyme in the mIns-producing pathway. In conclusion, noninvasive analysis of mIns using single-voxel MRS may be useful in distinguishing gliomas from other brain tumors, particularly PCNSLs.

収録刊行物

• Journal of neuro-oncology.

  Journal of neuro-oncology. 136 (2), 317-326, 2018-01

  Springer

キーワード

• Myo-inositol
• MR spectroscopy
• Primary central nervous system lymphoma
• Glioma
• Metabolomics

詳細情報

• CRID: 1050012570392493440
• NII論文ID: 120006769211
• ISSN: 15737373
• ISSN: 0167594X
• HANDLE: 20.500.14094/90006526
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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