Detection of Autoreactive Type II NKT Cells: A Pilot Study of Comparison Between Healthy Individuals and Patients with Vasculitis.

• Nishioka, Yusuke

• Sonoda, Takaomi

• Shida, Haruki

• Kusunoki, Yoshihiro

• Hattanda, Fumihiko

• Tanimura, Shun

• Uozumi, Ryo

• Yamada, Mai

• Nishibata, Yuka

• Masuda, Sakiko

• Nakazawa, Daigo

• Tomaru, Utano

• Atsumi, Tatsuya

• Ishizu, Akihiro

Abstract

NKT cells are defined as T cells that recognize hydrophobic antigens presented by class I MHC-like molecules, including CD1d. Among CD1d-restricted NKT cells, type I and type II subsets have been noted. CD1d-restricted type I NKT cells are regarded as pro-inflammatory cells in general. On the contrary, accumulated evidence has demonstrated an anti-inflammatory property of CD1d-restricted type II NKT cells. In our earlier study using a rat model with vasculitis, we demonstrated the pro-inflammatory function of CD1d-restricted type II NKT cells and identified that one such cell recognized P

Journal

• Cytometry. Part A : the journal of the International Society for Analytical Cytology

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 93 (11), 1157-1164, 2018-11

  Wiley

Keywords

• CD1d tetramer
• cytokine profile
• sterol carrier protein 2
• type II NKT cell
• vasculitis

Details

• CRID: 1050564289020304512
• NII Article ID: 120006769935
• DOI: 10.1002/cyto.a.23618
• HANDLE: 2115/76239
• ISSN: 15524930
• ISSN: 15524922
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcyto.a.23618
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1002/cyto.a.23618
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN