Intermittent parathyroid hormone 1-34 induces oxidation and detrioration of mineral and collagen quality in newly formed mandibular bone

• Yoshioka, Yohsuke

• Yamachika, Eiki

• Nakanishi, Makoto

• Ninomiya, Tadashi

• Akashi, Sho

• Kondo, Sei

• Moritani, Norifumi

• Kobayashi, Yasuhiro

• Fujii, Tatsuo

• Iida, Seiji

書誌事項

タイトル別名

• Intermittent parathyroid hormone 1-34 induces oxidation and deterioration of mineral and collagen quality in newly formed mandibular bone

抄録

Intermittent parathyroid hormone (PTH) administration is known to promote bone healing after surgical procedures. However, the mechanism and influence of PTH on the mineral and collagen quality of the jaw are not well understood. Most studies have focused on analyzing the bone density and microstructure of the mandible, and have insufficiently investigated its mineral and collagen quality. Oxidative stress activates osteoclasts, produces advanced glycation end products, and worsens mineral and collagen quality. We hypothesized that PTH induces oxidation and affects the mineral and collagen quality of newly formed mandibular bone. To test this, we examined the mineral and collagen quality of newly formed mandibular bone in rats administered PTH, and analyzed serum after intermittent PTH administration to examine the degree of oxidation. PTH administration reduced mineralization and worsened mineral and collagen quality in newly formed bone. In addition, total anti-oxidant capacity in serum was significantly decreased and the oxidative-INDEX was increased among PTH-treated compared to vehicle-treated rats, indicating serum oxidation. In conclusion, intermittent administration of PTH reduced mineral and collagen quality in newly formed mandibular bone. This effect may have been induced by oxidation.

収録刊行物

• Scientific Reports

  Scientific Reports 9 8041-, 2019-05-29

  Nature Publishing Group

キーワード

• Multidisciplinary

詳細情報

• CRID: 1050283687641746176
• NII論文ID: 120006777525
• ISSN: 20452322
• DOI: 10.1038/s41598-019-44389-8
• Web Site: https://ousar.lib.okayama-u.ac.jp/57797
• Web Site: https://www.nature.com/articles/s41598-019-44389-8.pdf
• Web Site: https://www.nature.com/articles/s41598-019-44389-8
• 本文言語コード: en
• 資料種別: journal article
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