Kabirimine, a New Cyclic Imine from an Okinawan Dinoflagellate
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- 東, 雅大
- Graduate School of Engineering and Science, University of the Ryukyus
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- Higa, Mikako
- Graduate School of Engineering and Science, University of the Ryukyus
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- Hutabarat, Philipus Uli Basa
- Graduate School of Engineering and Science, University of the Ryukyus
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- Fujiwara, Takeshi
- OP Bio Factory Co., Ltd.
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- Akiyama, Kiyotaka
- OP Bio Factory Co., Ltd.
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- Kanamoto, Akihiko
- OP Bio Factory Co., Ltd.
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- Haruyama, Takahiro
- Central Research Center, AVSS Corporation
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- Kobayashi, Nobuyuki
- Central Research Center, AVSS Corporation
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- Higashi, Masahiro
- Department of Molecular Engineering, Kyoto University
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- Suda, Shoichiro
- Department of Chemistry, Biology and Marine Science, University of the Ryukyus
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- Tanaka, Junichi
- Department of Chemistry, Biology and Marine Science, University of the Ryukyus
抄録
On our quest for new bioactive molecules from marine sources, two cyclic imines (1, 2) were isolated from a dinoflagellate extract, inhibiting the growth of the respiratory syncytial virus (RSV). Compound 1 was identified as a known molecule portimine, while 2 was elucidated to be a new cyclic imine, named kabirimine. The absolute stereochemistry of 1 was determined by crystallographic work and chiral derivatization, whereas the structure of 2 was elucidated by means of spectroscopic analysis and computational study on all the possible isomers. Compound 1 showed potent cytotoxicity (CC₅₀ < 0.097 µM) against HEp2 cells, while 2 exhibited moderate antiviral activity against RSV with IC₅₀ = 4.20 µM (95% CI 3.31–5.33).
収録刊行物
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- Marine drugs
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Marine drugs 17 (6), 353-, 2019-06
MDPI AG
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詳細情報 詳細情報について
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- CRID
- 1050565162618835584
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- NII論文ID
- 120006782210
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- ISSN
- 16603397
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- HANDLE
- 2433/245467
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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