Brachial‐Ankle Pulse Wave Velocity Versus Its Stiffness Index β‐Transformed Value as Risk Marker for Cardiovascular Disease

• Tomiyama, Hirofumi

• Ohkuma, Toshiaki

• Ninomiya, Toshiharu

• Nakano, Hiroki

• Matsumoto, Chisa

• Avolio, Alberto

• Kohro, Takahide

• Higashi, Yukihito

• Maruhashi, Tatsuya

• Takase, Bonpei

• Suzuki, Toru

• Ishizu, Tomoko

• Ueda, Shinichiro

• Yamazaki, Tsutomu

• Furumoto, Tomoo

• Kario, Kazuomi

• Inoue, Teruo

• Koba, Shinji

• Takemoto, Yasuhiko

• Hano, Takuzo

• Sata, Masataka

• Ishibashi, Yutaka

• Node, Koichi

• Maemura, Koji

• Ohya, Yusuke

• Furukawa, Taiji

• Ito, Hiroshi

• Chikamori, Taishiro

• Yamashina, Akira

Bibliographic Information

Other Title

• Blood Pressure and Arterial Stiffness

Abstract

Background—The difference in the predictive ability of the brachial-ankle pulse wave velocity (baPWV) and its stiffness index β-transformed value (β-baPWV, ie, baPWV adjusted for the pulse pressure) for the development of pathophysiological abnormalities related to cardiovascular disease or future occurrence of cardiovascular disease was examined. Methods and Results—In study 1, a 7-year prospective observational study in cohorts of 3274 men and 3490 men, the area under the curve in the receiver operator characteristic curve analysis was higher for baPWV than for β-baPWV for predicting the development of hypertension (0.73, 95% CI=0.70 to 0.75 versus 0.59, 95% CI=0.56 to 0.62; P<0.01) and/or the development of retinopathy (0.78, 95% CI=0.73 to 0.82 versus 0.66, 95% CI=0.60 to 0.71; P<0.01) by the end of the study period. During study 2, a 3-year observation period on 511 patients with coronary artery disease, 72 cardiovascular events were confirmed. The C statistics of both markers for predicting the development of cardiovascular events were similar. Conclusions—Stiffness index β transformation of the baPWV may attenuate the significance of the baPWV as a risk marker for development of pathophysiological abnormalities related to cardiovascular disease in male subjects.

Journal

• Journal of the American Heart Association

  Journal of the American Heart Association 8 (24), e013004-, 2019-12-11

  The American Heart Association

Keywords

• arterial stiffness
• blood pressure
• hypertension
• organ damage
• stiffness index β

Details

• CRID: 1050283688373664640
• NII Article ID: 120006786177
• ISSN: 20479980
• DOI: 10.1161/jaha.119.013004
• Web Site: https://repo.lib.tokushima-u.ac.jp/114188
• Web Site: https://www.ahajournals.org/doi/full/10.1161/JAHA.119.013004
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN