Adult-onset Still's disease with macrophage activation syndrome diagnosed and treated based on cytokine profiling: a case-based review

• Goda, Ken

• 見坂, 恒明

• Hoshijima, Masahiko

• Yachie, Akihiro

• Akita, Hozuka

抄録

Adult-onset Still's disease (AOSD) is a relatively rare systemic inflammatory disorder and is diagnosed using various sets of classification criteria, with the Yamaguchi criteria as the most widely used criteria. Herein, we present the case of a 21-year-old woman admitted with a high fever, lasting for over 1 month, who did not fulfill the Yamaguchi criteria. However, by analyzing the inflammatory cytokine profile, we defined this case as AOSD based on a greatly elevated serum interleukin-18 level. In addition, we predicted the occurrence of macrophage activation syndrome by a characteristic increase in the soluble tumor necrosis factor receptor II level, which allowed a timely intervention for this malicious complication. Therefore, we suggest that cytokine profiling will be useful for the diagnosis and management of AOSD.

収録刊行物

• Rheumatology International

  Rheumatology International 40 (1), 145-152, 2020-01

  Springer Nature

キーワード

• Adult-onset still's disease
• Cytokines
• Macrophage activation syndrome
• Diagnosis

詳細情報

• CRID: 1050294045369240448
• NII論文ID: 120006786955
• NII書誌ID: AA11630560
• ISSN: 1437160X
• ISSN: 01728172
• HANDLE: 20.500.14094/90006735
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles