A Promising New Anti-Cancer Strategy: Iron Chelators Targeting CSCs

• Chen Yuehua

• Ohara Toshiaki

• Xing Boyi

• Qi Jiping

• Noma Kazuhiro

• Matsukawa Akihiro

抄録

Iron is a trace but vital element in the human body and is necessary for a multitude of crucial processes in life. However, iron overload is known to induce carcinogenesis via oxidative stress. Cancer cells require large amounts of iron for their rapid division and cell growth. Iron was recently found to play a role in cancer stem cells (CSCs); it maintains stemness during development. Iron also plays an important role in stemness by moderating reactive oxygen species. Thus, iron metabolism in CSCs is a promising therapeutic target. In this review, we summarize the roles of iron in cancer cells and CSCs. We also summarize anti-cancer therapeutic studies with iron chelators and describe our expectation of a new therapeutic strategy for CSCs on the basis of our findings.

収録刊行物

• Acta Medica Okayama

  Acta Medica Okayama 74 (1), 1-6, 2020-02

  Okayama University Medical School

キーワード

• cancer stem cell
• stemness
• iron
• chelation
• chemotherapy

詳細情報

• CRID: 1390290699799382400
• NII論文ID: 120006795613
• NII書誌ID: AA00508441
• ISSN: 0386300X
• DOI: 10.18926/amo/57946
• Web Site: https://ousar.lib.okayama-u.ac.jp/57946
• 本文言語コード: en
• データソース種別:
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  • IRDB
  • CiNii Articles
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