Outcome of cesarean scar pregnancy treated with local methotrexate injection
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Local injection of methotrexate (MTX) has been widely used for caesarean scar pregnancy (CSP),but the optimal candidate remains undetermined. The aim of this study is to determine the risk factors associated with treatment failure among patients who received a single dose of local MTX. This is a retrospective cohort study. Clinical information was compared between treatment success vs. failure groups. Risk factors related to treatment failure were also investigated with multivariate analysis. Of 47 patients diagnosed with CSP, 30 received local MTX injection. The initial serum ß- human chorionic gonadotropin (hCG) level in the failure group was significantly higher than in the success group (p = 0.048), and the cut-off value was 47,000 mIU/ml. The rate of type 2 position of the gestational sac in the failure group was significantly higher than in the treatment success group (p = 0.031). A high initial serum ß-hCG level (≥ 47,000 mIU/ml) was identified as the independent risk factor for treatment failure (adjusted odds ratio = 21.9; 95% confidence interval = 1.3–383.1). Type 2 gestational sac position and a higher level of ß-hCG at diagnosis appear to be associated with poor outcomes after local injection of a single dose of MTX.
収録刊行物
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- Nagoya Journal of Medical Science
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Nagoya Journal of Medical Science 82 (1), 15-23, 2020-02
Nagoya University Graduate School of Medicine, School of Medicine
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詳細情報 詳細情報について
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- CRID
- 1390572174577925120
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- NII論文ID
- 120006797868
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- ISSN
- 21863326
- 00277622
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- HANDLE
- 2237/00031535
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用可