Effects of low-level prenatal exposure to dioxins on cognitive development in Japanese children at 42 months

• Ikeno, Tamiko

• Miyashita, Chihiro

• Nakajima, Sonomi

• Kobayashi, Sumitaka

• Yamazaki, Keiko

• Saijo, Yasuaki

• Kita, Toshiko

• Sasaki, Seiko

• Konishi, Kanae

• Kajiwara, Junboku

• Hori, Tsuguhide

• Kishi, Reiko

抄録

Background: Prenatal exposure to polychlorinated dibenzo-p-dioxins (PCDDs) or polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dioxin-like compounds [DLCs]) through environmental chemicals may affect the neurodevelopment of children. In our previous study, an inverse association was observed between prenatal DLCs and neurodevelopment of infants aged 6 months in both sexes. However, studies are yet to determine how long these adverse effects last. Objective: To examine whether the effects of DLCs on cognitive development remains at 42 months. Methods: In this prospective cohort study conducted in Sapporo, Japan, pregnant mothers' blood was analyzed for the congener level of DLCs. The Kaufman Assessment of Battery for Children (K-ABC) was used to test their children's cognitive development at 42 months. A total of 141 mother-child pairs were included in the final analysis. The multiple linear regression analysis was used to examine the association between the K-ABC scores and DLC levels in the maternal blood. Results: Seven isomers (1,2,3,6,7,8-HxCDD, 2,3,4,7,8-PeCDF, 33'44'55'-HxCB(#169), 2344'5-PenCB(#114), 233'44'5-HexCB(#156), 233'44'5'-HexCB(#157), 23'44'55'-HexCB(#167), total PCDF, and TEQ-PCDD, PCDF, PCDD/DFs levels were positively associated with the achievement score (AS) of K-ABC. However, total non-ortho PCBs were negatively associated with the Mental Processing Composite Score (MPCS) of K-ABC in males. In females, increased TEQ-dl PCB and TEQ-PCDD/F/dl-PCB were also associated with increasing AS score. Conclusions: This study suggests that the negative effects of prenatal DLC exposure on children's cognitive development at 6 months were not observed in children aged 42 months. Regarding the sex-specific effects, AS and DLCs were positively correlated in females, whereas those of MPCS and DLCs were significantly negative in males.

収録刊行物

• Science of the total environment

  Science of the total environment 618 1423-1430, 2018-03-15

  Elsevier

キーワード

• Birth-cohort study
• Dioxin-like compounds
• Prenatal exposure
• Cognitive development
• Kaufman Assessment of Battery for Children

詳細情報

• CRID: 1050846637964107008
• NII論文ID: 120006812530
• DOI: 10.1016/j.scitotenv.2017.09.267
• HANDLE: 2115/76951
• ISSN: 00489697
• Web Site: https://api.elsevier.com/content/article/PII:S0048969717326086?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0048969717326086?httpAccept=text/plain
• 本文言語コード: en
• 資料種別: journal article
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