Intravoxel incoherent motion (IVIM) and non-Gaussian diffusion MRI of the lactating breast

• 飯間, 麻美

  Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine・The Hakubi Center for Advanced Research, Kyoto University

• 片岡, 正子

  Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine

• 金尾, 昌太郎

  Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine

• 大西, 奈都子

  Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine

• 河合, 真喜子

  Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine

• 大橋, 茜

  Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine

• 村田, 勝俊

  Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine

• 富樫, かおり

  Siemens Japan K.K.

• Togashi, Kaori

  Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine

抄録

Purpose: To investigate the effect of breastfeeding on IVIM and non-Gaussian diffusion MRI in the breast. Materials and methods: An IRB approved prospective study enrolled seventeen volunteers (12 in lactation and 5 with post-weaning, range 31–43 years; mean 35.4 years). IVIM (fIVIM and D*) and non-Gaussian diffusion (ADC₀ and K) parameters using 16 b values, plus synthetic apparent diffusion coefficients (sADCs) from 2 key b values (b = 200 and 1500 s/mm²) were calculated using regions of interest. ADC₀ maps of the whole breast were generated and their contrast patterns were evaluated by two independent readers using retroareolar and segmental semi-quantitative scores. To compare the diffusion and IVIM parameters, Wilcoxon signed rank tests were used between pre- and post-breastfeeding and Mann-Whitney tests were used between post-weaning and pre- or post-breastfeeding. Results: ADC₀ and sADC values significantly decreased post-breastfeeding (1.90 vs. 1.72 × 10⁻³mn²/s, P < 0.001) while K values significantly increased (0.33 vs. 0.44, P < 0.05). fIVIM values significantly increased after breastfeeding (1.97 vs. 2.97%, P < 0.01). No significant difference was found in D* values. There was significant heterogeneity in ADC₀ maps post-breastfeeding, both in retroareolar and segmental scores (P < 0.0001 and =0.0001). Conclusion: IVIM and non-Gaussian diffusion parameters significantly changed between pre- and post-breastfeeding status, and care needs to be taken in interpreting diffusion-weighted imaging (DWI) data in lactating breasts.

収録刊行物

• European Journal of Radiology Open

  European Journal of Radiology Open 5 24-30, 2018

  Elsevier BV

キーワード

• Diffusion-weighted imaging
• Intravoxel incoherent motion
• Kurtosis
• Lactation
• Breast

詳細情報

• CRID: 1050283688375754240
• NII論文ID: 120006817601
• ISSN: 23520477
• DOI: 10.1016/j.ejro.2018.01.003
• HANDLE: 2433/246439
• Web Site: https://api.elsevier.com/content/article/PII:S2352047718300030?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S2352047718300030?httpAccept=text/plain
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN