Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head

• 坂本, 悠磨

• 山本, 卓明

• 菅野, 伸彦

• 髙橋, 大介

• 渡邊, 俊之

• 渥美, 敬

• 中村, 順一

• 長谷川, 幸治

• 赤司, 浩一

• 成田, 一衛

• 宮本, 健史

• 竹内, 勤

• 猪狩, 勝則

• 天野, 宏一

• 藤江, 厚廣

• 久保, 俊一

• 多田, 芳史

• 兼氏, 歩

• 中村, 博亮

• 宮村, 知也

• 加畑, 多文

• 山路, 健

• 大川, 孝浩

• 湏藤, 啓広

• 大園, 健二

• 田中, 良哉

• 安永, 裕司

• 松田, 秀一

• 今井, 祐記

• 秋山, 雅人

• 久保, 充明

• 鎌谷, 洋一郎

• 岩本, 幸英

• 池川, 志郎

抄録

Idiopathic osteonecrosis of the femoral head (IONFH) is an ischemic disorder that causes bone necrosis of the femoral head, resulting in hip joint dysfunction. IONFH is a polygenic disease and steroid and alcohol have already known to increase its risk; however, the mechanism of IONFH remains to be elucidated. We performed a genome-wide association study using ~60, 000 subjects and found two novel loci on chromosome 20q12 and 12q24. Big data analyses identified LINC01370 as a candidate susceptibility gene in the 20q12 locus. Stratified analysis by IONFH risk factors suggested that the 12q24 locus was associated with IONFH through drinking capacity. Our findings would shed new light on pathophysiology of IONFH.

収録刊行物

• Scientific Reports

  Scientific Reports 7 15035-, 2017-11-08

  Springer Nature

キーワード

• Bone
• Genome-wide association studies
• Musculoskeletal abnormalities
• Osteoarthritis

詳細情報

• CRID: 1050002213034251264
• NII論文ID: 120006817606
• ISSN: 20452322
• DOI: 10.1038/s41598-017-14778-y
• HANDLE: 2433/246546
• Web Site: https://www.nature.com/articles/s41598-017-14778-y.pdf
• Web Site: https://www.nature.com/articles/s41598-017-14778-y
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN