A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes
Abstract
To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5, 768, 242 single nucleotide polymorphisms (SNPs) in Japanese patients with type 2 diabetes, 2, 380 nephropathy cases and 5, 234 controls. We further performed GWAS for diabetic nephropathy using independent Japanese patients with type 2 diabetes, 429 cases and 358 controls and the results of these two GWAS were combined with an inverse variance meta-analysis (stage-1), followed by a de novo genotyping for the candidate SNP loci (p < 1.0 × 10−4) in an independent case-control study (Stage-2; 1, 213 cases and 1, 298 controls). After integrating stage-1 and stage-2 data, we identified one SNP locus, significantly associated with diabetic nephropathy; rs56094641 in FTO, P = 7.74 × 10−10. We further examined the association of rs56094641 with diabetic nephropathy in independent Japanese patients with type 2 diabetes (902 cases and 1, 221 controls), and found that the association of this locus with diabetic nephropathy remained significant after integrating all association data (P = 7.62 × 10−10). We have identified FTO locus as a novel locus for conferring susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.
Journal
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- PLOS ONE
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PLOS ONE 13 (12), 2018-12-19
Public Library of Science (PLoS)
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Details 詳細情報について
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- CRID
- 1050002213399821312
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- NII Article ID
- 120006822492
- 120006889944
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- ISSN
- 19326203
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- HANDLE
- 2433/250039
- 20.500.12000/46886
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- CiNii Articles