Association of cholesterol uptake capacity, a novel indicator for HDL functionality, and coronary plaque properties: An optical coherence tomography-based observational study

• Oshita, Toshihiko

• 杜, 隆嗣

• Nagano, Yuichiro

• Kuroda, Koji

• Nagasawa, Yoshinori

• Harada, Amane

• Murakami, Katsuhiro

• Kiriyama, Maria

• Yoshikawa, Keiko

• Miwa, Keiko

• Kubo, Takuya

• Iino, Takuya

• 長尾, 学

• 入野, 康宏

• 原, 哲也

• 篠原, 正和

• 大竹, 寛雅

• 新家, 俊郎

• Nakajima, Katsuyuki

• 石田, 達郎

• 平田, 健一

抄録

Background: Cholesterol efflux from atherosclerotic lesion is a key function of high-density lipoprotein (HDL). Recently, we established a simple, high-throughput, cell-free assay to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as "cholesterol uptake capacity (CUC)". Objective: To clarify the cross-sectional relationship between CUC and coronary plaque properties. Methods: We enrolled 135 patients to measure CUC and assess the morphological features of angiographic stenosis by optical coherence tomography (OCT). We estimated the extent of the lipid-rich plaque by multiplying the mean lipid arc by lipid length (lipid index). The extent of the OCT-detected macrophage accumulation in the target plaque was semi-quantitatively estimated using a grading system. Results: Lipid-rich plaque lesions were identified in 125 patients (92.6%). CUC was inversely associated with the lipid index (R = -0.348, P < 0.0001). In addition, CUC was also inversely associated with macrophage score (R = - 0.327, P < 0.0001). Conversely, neither circulating levels of HDL cholesterol nor apoA1 showed a similar relationship. Conclusions: We demonstrated that CUC was inversely related to lipid-rich plaque burden and the extent of macrophage accumulation, suggesting that CUC could be useful for cardiovascular risk stratification.

収録刊行物

• Clinica Chimica Acta

  Clinica Chimica Acta 503 136-144, 2020-04

  Elsevier B.V.

キーワード

• High-density lipoprotein (HDL)
• Cholesterol uptake capacity (CUC)
• Cholesterol efflux capacity (CEC)
• Coronary plaque
• Optical coherence tomography (OCT)
• Lipid index
• Macrophage score

詳細情報

• CRID: 1050856995322858112
• NII論文ID: 120006824021
• NII書誌ID: AA00607421
• DOI: 10.1016/j.cca.2020.01.001
• ISSN: 18733492
• ISSN: 00098981
• HANDLE: 20.500.14094/90007007
• Web Site: https://api.elsevier.com/content/article/PII:S0009898120300012?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0009898120300012?httpAccept=text/plain
• 本文言語コード: en
• 資料種別: journal article
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