ヒト臓器・組織置換マウス等を用いた宇宙放射線の人体および継世代リスクの基礎評価

• 野村, 大成

• 梁, 治子

• 足立, 成基

• 中島, 裕夫

• 本行, 忠志

• 藤川, 和男

• 伊藤, 哲夫

• 松塚, 文夫

• Nomura, Taisei

• Ryo, Haruko

• Adachi, Shigeki

• Nakajima, Hiroo

• Hongyo, Tadashi

• Fujikawa, Kazuo

• Itoh, Tetsuo

• Matsuzuka, Fumio

書誌事項

タイトル別名

• Risk of cosmic radiation on human organs and tissues maintained in SCID mice and transgenerational effects

抄録

第25回宇宙利用シンポジウム(2009年1月14日-15日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス)

The Twenty-fifth Space Utilization Symposium (January 14-15, 2009: ISAS/JAXA Sagamihara, Japan)

To study the risk of cosmic radiation, two projects, effects on human organs and tissues maintained in super-SCID mice and transgenerational effects in the offspring of mice exposed to radiation were carried out;. Morphological and functional (hormone secretion) changes and/or mutations were induced in human thyroid tissues by high doses and high dose rate of X- and gamma-rays (9-33 Gy) and reactor neutron (0.2 Gy x 6), but not by same doses with low dose-rate of gamma-rays, showing apparent dose rate effects in human thyroid tissues. Neutron (0.2 Gy x 4) induced bigger changes in gene expression than 2 Gy of gamma-rays, suggesting high RBE of neutron. Microsatellite mutations and lymphocytic leukemia were induced dose-dependently in the offspring of N5 male mice exposed to 0.2 and 0.4 Gy of neutron. The incidence was 10 folds higher than our former X-ray and gamma-ray studies, again suggesting high RBE.

形態: カラー図版あり

資料番号: AA0064297016

収録刊行物

• 宇宙利用シンポジウム = Space Utilization Research: Proceedings of Space Utilization Symposium

  宇宙利用シンポジウム = Space Utilization Research: Proceedings of Space Utilization Symposium 25 2009-03

  宇宙航空研究開発機構宇宙科学研究本部

キーワード

• Space Radiation, Neutron, Human Thyroid Gland, SCID Mice, Microsatellite Mutation, Leukemia, F(sub 1) Progeny

詳細情報

• CRID: 1050011086285544448
• NII論文ID: 120006830504
• NII書誌ID: AN10324210
• Web Site: http://id.nii.ac.jp/1696/00013254/
• 本文言語コード: ja
• 資料種別: conference paper
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