ヒト臓器・組織置換マウス等を用いた宇宙放射線の人体および継世代リスクの基礎評価

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  • Risk of cosmic radiation on human organs and tissues maintained in SCID mice and transgenerational effects

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Abstract

第25回宇宙利用シンポジウム(2009年1月14日-15日, 宇宙航空研究開発機構宇宙科学研究本部相模原キャンパス)

The Twenty-fifth Space Utilization Symposium (January 14-15, 2009: ISAS/JAXA Sagamihara, Japan)

To study the risk of cosmic radiation, two projects, effects on human organs and tissues maintained in super-SCID mice and transgenerational effects in the offspring of mice exposed to radiation were carried out;. Morphological and functional (hormone secretion) changes and/or mutations were induced in human thyroid tissues by high doses and high dose rate of X- and gamma-rays (9-33 Gy) and reactor neutron (0.2 Gy x 6), but not by same doses with low dose-rate of gamma-rays, showing apparent dose rate effects in human thyroid tissues. Neutron (0.2 Gy x 4) induced bigger changes in gene expression than 2 Gy of gamma-rays, suggesting high RBE of neutron. Microsatellite mutations and lymphocytic leukemia were induced dose-dependently in the offspring of N5 male mice exposed to 0.2 and 0.4 Gy of neutron. The incidence was 10 folds higher than our former X-ray and gamma-ray studies, again suggesting high RBE.

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資料番号: AA0064297016

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