重粒子線低密度照射による突然変異誘発効果の遺伝的不安定性の誘導

• 鈴木, 雅雄

• Suzuki, Masao

書誌事項

タイトル別名

• Genomic instability in mutation induction induced by low-fluence particle radiations

抄録

We have studied biological effects in normal human fibroblasts induced by low-fluence high-LET (Linear Energy Transfer) ions to examine what kinds of radiation species induce genomic instability. Cells were pre-treated with low-fluence ions (approximately 1 milli-Gy/7 to 8 h) of either carbon or helium before following irradiation with X-ray challenging dose (1.5 Gy). There observed no difference in cell-killing effect in pre-treatment with either carbon or helium, when comparing to the pre-treatment with low-dose Cs-137 gamma rays. In mutation induction there was no difference in induced mutation frequency at 1.5 Gy of X-ray challenging dose between un-pretreated and gamma-ray pre-treated cells. On the other hand, it was around 4.0 times higher in carbon-ion pre-treated cells and 1.9 times higher in helium-ion pre-treated cells than in un-pretreated cells. There is evidence that genomic instability in mutation induction induced by the pre-treatment of low-fluence ions depends upon both LET and ion species.

資料番号: AA0063349086

収録刊行物

• 宇宙利用シンポジウム　第23回　平成18年度 = Space Utilization Research: Proceedings of the Twenty-third Space Utilization Symposium

  宇宙利用シンポジウム　第23回　平成18年度 = Space Utilization Research: Proceedings of the Twenty-third Space Utilization Symposium 302-304, 2007-03

  宇宙航空研究開発機構宇宙科学研究本部

キーワード

• イオンビーム
• 中性子ビーム
• 放射線曝露
• 遺伝的不安定性
• 繊維芽細胞
• 低流束照射
• 宇宙放射線
• 放射線影響
• 細胞
• 生物学的影響
• 線形エネルギー転送
• 突然変異
• バイスタンダー効果
• ion beam
• neutron beam
• radiation exposure
• genomic instability
• fibroblast
• low- fluence radiation
• space radiation
• radiation effect
• cell
• biological effect
• linear energy transfer (LET)
• mutation
• bystander effect

詳細情報

• CRID: 1050855511201196416
• NII論文ID: 120006830828
• Web Site: http://id.nii.ac.jp/1696/00013578/
• 本文言語コード: ja
• 資料種別: conference paper
• データソース種別:
  • IRDB
  • CiNii Articles
  • KAKEN