魚類のウロコを用いた宇宙生物学的研究

• 鈴木, 信雄

• 大森, 克徳

• 井尻, 憲一

• 北村, 敬一郎

• 清水, 宣明

• 田畑, 純

• 池亀, 美華

• 中村, 正久

• 近藤, 隆

• 松田, 恒平

• Suzuki, Nobuo

• Omori, Katsunori

• Ijiri, Kenichi

• Kitamura, Keiichiro

• Shimizu, Nobuaki

• Tabata, Makoto J.

• Ikegame, Mika

• Nakamura, Masahisa

• Kondo, Takashi

• Matsuda, Kohei

Bibliographic Information

Other Title

• Space biology utilizing fish scale

Abstract

In osteoclast activity during space flight, inconsistent results have been reported in an in vivo study while osteoblastic function is consistently reduced by space flight. Bone matrix is an important function in the response to physical stress. However, there is no suitable in vitro co-culture system of osteoblasts and osteoclasts including bone matrix. On the other hand, fish scale is a calcified tissue that contains osteoblasts, osteoclasts, and bone matrix, all of which are similar to those found in human bones. Recently, we developed a new in vitro model system using goldfish scale. This system can be used to simultaneously detect the activities of both scale osteoclasts and osteoblasts with tartrate-resistant acid phosphatase and alkaline phosphatase as the respective markers and precisely analyze the co-relationship between osteoblasts and osteoclasts. In our co-culture system, osteoblasts and osteoclasts reacted sensitively to several degrees of acceleration, ultrasound stimulation, and micro-gravity of 3D clinostat. Therefore, we strongly believe that our in vitro co-culture system is suitable model for the analysis of bone metabolism under micro-gravity, such as that experienced in space flight.

資料番号: AA0063349091

Journal

• 宇宙利用シンポジウム　第23回　平成18年度 = Space Utilization Research: Proceedings of the Twenty-third Space Utilization Symposium

  宇宙利用シンポジウム　第23回　平成18年度 = Space Utilization Research: Proceedings of the Twenty-third Space Utilization Symposium 318-321, 2007-03

  宇宙航空研究開発機構宇宙科学研究本部

Keywords

• 魚
• 魚類のウロコ
• 骨芽細胞
• 破骨細胞
• 宇宙生物学
• 高重力環境
• 超音波
• クリノスタット
• 微小重力
• 骨
• 重力効果
• 機械的ストレス
• エストローゲン受容体
• 酒石酸塩耐性酸性燐酸分解酵素
• fish
• fish scale
• osteoblast
• osteoclast
• exobiology
• high gravity environment
• ultrasonic wave
• clinostat
• microgravity
• bone
• gravitational effect
• mechanical stress
• estrogen receptor
• tartrate-resistant acid phosphatase

Details

• CRID: 1050855511215586432
• NII Article ID: 120006830833
• Web Site: http://id.nii.ac.jp/1696/00013583/
• Text Lang: ja
• Article Type: conference paper
• Data Source:
  • IRDB
  • CiNii Articles
  • KAKEN