培養アストロサイトにおける低線量放射線応答タンパクの解析

• 三浦, ゆり

• 加納, まゆみ

• 鈴木, 捷三

• 戸田, 年総

• Miura, Yuri

• Kano, Mayumi

• Suzuki, Shozo

• Toda, Tosifusa

書誌事項

タイトル別名

• Low dose radiation-responsive proteins in cultured astrocytes

抄録

第22回宇宙利用シンポジウム(2006年1月17日-19日, 日本学術会議6階会議室 六本木、東京)

The Twenty-second Space Utilization Symposium (January 17-19, 2006: Science Council of Japan, Roppongi, Tokyo, Japan)

Ionizing radiation causes various damages, carcinogenesis or cell death. However, low dose irradiation is reported to give rise to adaptive responses. We have reported that radiation adaptive response was observed in cultured astrocytes from young rats, and that the response was decreased with aging. In order to investigate the mechanisms of radiation adaptive response in cultured astrocytes, in the present study, we analyzed the variant expressions and phosphorylation of proteins in cell using proteomics. As a result, the fragmentation of elongation factor 2 was temporarily increased and elongation factor 1-beta was de-phosphorylated after low dose irradiation.

共催: 日本学術会議

Meeting sponsors: The Science Council of Japan, The Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (ISAS)(JAXA)

資料番号: AA0064113063

収録刊行物

• 宇宙利用シンポジウム = Space Utilization Research: Proceedings of Space Utilization Symposium

  宇宙利用シンポジウム = Space Utilization Research: Proceedings of Space Utilization Symposium 22 2006-03

  宇宙航空研究開発機構宇宙科学研究本部

キーワード

• low dose radiation, radiation adaptive response, proteomics, phosphorylation, aging, 2-D PAGE

詳細情報

• CRID: 1050292561262164864
• NII論文ID: 120006830923
• NII書誌ID: AN10324210
• Web Site: http://id.nii.ac.jp/1696/00013674/
• 本文言語コード: ja
• 資料種別: conference paper
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