Detection of hemodynamic characteristics before growth in growing cerebral aneurysms by analyzing time-of-flight magnetic resonance angiography images alone—preliminary results

• 木村, 英仁

• 林, 公祐

• 谷口, 理章

• 細田, 弘吉

• 藤田, 敦史

• Seta, Takeshi

• 冨山, 明男

• 甲村, 英二

書誌事項

タイトル別名

• Detection of Hemodynamic Characteristics Before Growth in Growing Cerebral Aneurysms by Analyzing Time-of-Flight Magnetic Resonance Angiography Images Alone: Preliminary Results

抄録

OBJECTIVE: Cerebral aneurysm growth often precedesrupture. Definite contributors to aneurysm growth have notbeen determined even by means of recently developedcommercially available computational fluid dynamics(CFD) software. We developed an original CFD tool that cananalyze data from time-of-flight magnetic resonance angi-ography (TOF-MRA) before growth in the growing aneu-rysms and investigate possible factors for aneurysmgrowth in the near future. METHODS: We retrospectively reviewed unrupturedaneurysms that were treated at our institute because ofaneurysm growth (growing group) between April 2013 andMarch 2017. Stable aneurysms that had demonstrated nogrowth for more than 5 years were selected (stable group).TOF-MRA data of these aneurysms were retrospectivelyconverted to 3-dimensional vessel geometric data; 3 he-modynamic indices including streamline, wall shear stress(WSS), and oscillatory shear index were calculated by ouroriginal CFD tool using the lattice Boltzmann method toquantitatively compare the 2 groups. RESULTS: Six growing aneurysms and 6 stable aneu-rysms were analyzed. Of the 6 growing aneurysms, WSS onthe focal aneurysmal sac increased temporally in thevicinity of the constant low WSS area at the peak systolicphase. By contrast, WSS did not increase during any part ofthe cardiac cycle in 3 of the 6 stable aneurysms. The peakvalues of WSS were significantly different between the 2groups. CONCLUSIONS: A focal increase in WSS in the peaksystolic phase may be a risk factor for aneurysm enlarge-ment in the near future.

収録刊行物

• World Neurosurgery

  World Neurosurgery 122 e1439-e1448, 2019-02

  Elsevier

キーワード

• Cerebral aneurysm
• Computational fluid dynamics
• Enlargement
• Growing
• Magnetic resonance angiography

詳細情報

• CRID: 1050294045369280640
• NII論文ID: 120006840183
• DOI: 10.1016/j.wneu.2018.11.081
• HANDLE: 20.500.14094/90007039
• ISSN: 18788750
• Web Site: https://api.elsevier.com/content/article/PII:S1878875018326317?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S1878875018326317?httpAccept=text/plain
• 本文言語コード: en
• 資料種別: journal article
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