臨床的放射線耐性細胞のこれまでとこれから

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タイトル別名
  • Clinically Relevant Radioresistant Cells; Past History and Future Plans
  • リンショウテキ ホウシャセン タイセイ サイボウ ノ コレマデ ト コレカラ

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抄録

Radiotherapy is one of the major modalities for the treatment of human cancers and has been established as an excellent local treatment for malignant tumors. To know the molecular mechanisms of radioresistant cells we made a system to compare between radioresistant and sensitive cells with the isogenic background. These cells continue to proliferate under exposure to 2 Gy/day X-rays for more than 30 days. Therefore, we named them clinically relevant radioresistant（CRR）cells. however, molecular mechanisms of CRR cell radioresistance remains to be elucidated so far. in this review new methodologies to know the molecular mechanisms of CRR cell radioresistance will be discussed.

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