Anemia Is a Novel Predictive Factor for the Onset of Severe Chemotherapy-Induced Peripheral Neuropathy in Lymphoma Patients Receiving Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisolone Therapy

• Saito, Takashi

• Okamura, Atsuo

• Inoue, Junichiro

• Makiura, Daisuke

• Doi, Hisayo

• Yakushijin, Kimikazu

• Matsuoka, Hiroshi

• Sakai, Yoshitada

• Ono, Rei

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) frequently occurs in lymphoma patients receiving R-CHOP, a drug combination therapy. Although severe CIPN may lead to reduction and/or discontinuation of the medication, predictive factors of CIPN have not been investigated sufficiently to date. We performed a retrospective exploratory research to determine associations between prevalence of severe CIPN and socio-demographic data, health characteristics, and medical conditions such as anemia at initial diagnosis. Forty patients (indolent lymphoma, n = 9; diffuse large B-cell lymphoma; n = 31) received R-CHOP therapy from September 2009 to July 2014. The median age of patients was 58 years (range = 27–76 years). Statistical analy-ses were applied to the patients, who were divided into two groups: mild CIPN (no symptoms or grade 1 according to the CTCAE version 3.0 program) and severe CIPN patients (grade 2 or higher). Forward stepwise logistic regression analyses were performed using the following variables: sex, BMI, BSA, hyperglycemia, malnutrition, and anemia. Severe CIPN occurred in seven patients (17.5%). Gender and anemia remained following the stepwise procedure, and anemia predicted severe CIPN significantly (OR = 19.45, 95% confi-dence interval = 1.52–171.12). Our study suggests that anemia at initial diagnosis could be a predictive factor of R-CHOP-induced CIPN.

Journal

• Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics

  Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 27 (4), 469-474, 2019-03-29

  Cognizant Communication Corporation

Keywords

• Chemotherapy-induced peripheral neuropathy (CIPN)
• Anemia
• R-CHOP
• Diffuse large B-cell lymphoma (DLBCL)

Details

• CRID: 1050575520345784576
• NII Article ID: 120006867199
• DOI: 10.3727/096504018x15267574931782
• ISSN: 15553906
• ISSN: 09650407
• HANDLE: 20.500.14094/90007193
• Web Site: https://www.ingentaconnect.com/content/cog/or/2019/00000027/00000004/art00009
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN