Prostaglandin E2 and its receptor EP2 trigger signaling that contributes to YAP-mediated cell competition
Bibliographic Information
- Other Title
-
- Prostaglandin E<sub>2</sub> and its receptor EP2 trigger signaling that contributes to YAP‐mediated cell competition
Search this article
Abstract
Cell competition is a biological process by which unfit cells are eliminated from "cell society." We previously showed that cultured mammalian epithelial Madin-Darby canine kidney (MDCK) cells expressing constitutively active YAP were eliminated by apical extrusion when surrounded by "normal" MDCK cells. However, the molecular mechanism underlying the elimination of active YAP-expressing cells was unknown. Here, we used high-throughput chemical compound screening to identify cyclooxygenase-2 (COX-2) as a key molecule triggering cell competition. Our work shows that COX-2-mediated PGE2 secretion engages its receptor EP2 on abnormal and nearby normal cells. This engagement of EP2 triggers downstream signaling via an adenylyl cyclase-cyclic AMP-PKA pathway that, in the presence of active YAP, induces E-cadherin internalization leading to apical extrusion. Thus, COX-2-induced PGE(2) appears a warning signal to both abnormal and surrounding normal cells to drive cell competition.
Journal
-
- Genes to Cells
-
Genes to Cells 25 (3), 197-214, 2020-03
Wiley
- Tweet
Details 詳細情報について
-
- CRID
- 1050856995322408576
-
- NII Article ID
- 120006873037
-
- NII Book ID
- AA11078945
-
- ISSN
- 13652443
- 13569597
-
- HANDLE
- 20.500.14094/90007259
-
- Text Lang
- en
-
- Article Type
- journal article
-
- Data Source
-
- IRDB
- Crossref
- CiNii Articles
- KAKEN