Serological evidence of Zika virus infection in non-human primates in Zambia

• Wastika, Christida E.

• Sasaki, Michihito

• Yoshii, Kentaro

• Anindita, Paulina D.

• Hang'ombe, Bernard M.

• Mweene, Aaron S.

• Kobayashi, Shintaro

• Kariwa, Hiroaki

• Carr, Michael J.

• Hall, William W.

• Eshita, Yuki

• Orba, Yasuko

• Sawa, Hirofumi

抄録

Zika virus (ZIKV) circulation occurs between non-human primates (NHPs) in a sylvatic transmission cycle. To investigate evidence of flavivirus infection in NHPs in Zambia, we performed a plaque reduction neutralization test (PRNT) to quantify neutralizing antibodies. PRNT revealed that sera from NHPs (African green monkeys and baboons) exhibited neutralizing activity against ZIKV (34.4%; 33/96), whereas a PRNT for yellow fever virus using NHP sera showed no neutralization activity. ZIKV genomic RNA was not detected in splenic tissues from NHPs, suggesting that the presence of anti-ZIKV neutralizing antibodies represented resolved infections. Our evidence suggests that ZIKV is maintained in NHP reservoirs in Zambia.

収録刊行物

• Archives of virology

  Archives of virology 164 (8), 2165-2170, 2019-08

  Springer

キーワード

• Zika virus

詳細情報

• CRID: 1050003824926913664
• NII論文ID: 120006876275
• DOI: 10.1007/s00705-019-04302-0
• ISSN: 14328798
• ISSN: 03048608
• HANDLE: 2115/79038
• Web Site: http://link.springer.com/content/pdf/10.1007/s00705-019-04302-0.pdf
• Web Site: http://link.springer.com/article/10.1007/s00705-019-04302-0/fulltext.html
• 本文言語コード: en
• 資料種別: journal article
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