Investigation of energy absorption by clustered gold nanoparticles

• Kwon, Jihun

• Sutherland, Kenneth

• Makarova, Anastasia

• Matsuura, Taeko

• Hashimoto, Takayuki

• Peng, Hao

• Toshito, Toshiyuki

• Umegaki, Kikuo

• Shirato, Hiroki

• Shimizu, Shinichi

抄録

The utilization of gold nanoparticles (GNPs) as a radiation sensitizer has received broad attention. Although GNPs form clusters in living cells, most previous simulation studies have assumed a homogeneous distribution of GNPs. In this study, a GNP cluster was constructed for simulations and the impact of cluster formation on dose enhancement was examined. Energy absorption by the GNPs was compared between clustered and homogeneous distributions for several different GNP concentrations and diameters under 100 keV X-ray irradiations. Our simulations showed that clusters more efficiently absorbed the secondary electrons and photons produced by GNPs themselves. Furthermore, the impact of cluster formation on dose enhancement was more significant for smaller GNPs and higher concentrations. Our results suggest that previous simulations assuming a homogeneous GNP distribution have overestimated the dose enhancement, especially for smaller GNPs and higher concentrations. These findings should guide the selection of GNP size and concentration for effectively optimizing dose enhancement in future studies.

収録刊行物

• Nuclear instruments & methods in physics research section b-beam interactions with materials and atoms

  Nuclear instruments & methods in physics research section b-beam interactions with materials and atoms 429 34-41, 2018-08-15

  Elsevier

キーワード

• Gold nanoparticles
• Clustering
• Dose enhancement
• Radiation sensitizer
• Monte Carlo simulation

詳細情報

• CRID: 1050285299932368896
• NII論文ID: 120006878347
• DOI: 10.1016/j.nimb.2018.05.033
• HANDLE: 2115/79061
• ISSN: 0168583X
• Web Site: https://api.elsevier.com/content/article/PII:S0168583X18303495?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0168583X18303495?httpAccept=text/plain
• 本文言語コード: en
• 資料種別: journal article
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