Cytotoxic Effects of Alcohol Extracts from a Plastic Wrap (Polyvinylidene Chloride) on Human Cultured Liver Cells and Mouse Primary Cultured Liver Cells

• Yamamoto Ken-ichi

• Kagawa Hiroko

• Arimoto Sakae

• Tan Xian Wen

• Yasui Kento

• Oshiki Toshiyuki

• Sakaguchi Masakiyo

抄録

An increasing accumulation of microplastics and further degraded nanoplastics in our environment is suspected to have harmful effects on humans and animals. To clarify this problem, we tested the cytotoxicity of two types of plastic wrap on human cultured liver cells and mouse primary cultured liver cells. Alcohol extracts from plastic wrap, i.e., polyvinylidene chloride (PVDC), showed cytotoxic effects on the cells. Alcohol extracts of polyethylene (PE) wrap were not toxic. The commercially available PVDC wrap consists of vinylidene chloride, epoxidized soybean oil, epoxidized linseed oil as a stiffener and stabilizer; we sought to identify which component(s) are toxic. The epoxidized soybean oil and epoxidized linseed oil exerted strong cytotoxicity, but the plastic raw material itself, vinylidene chloride, did not. Our findings indicate that plastic wraps should be used with caution in order to prevent health risks.

収録刊行物

• Acta Medica Okayama

  Acta Medica Okayama 74 (4), 327-334, 2020-08

  Okayama University Medical School

キーワード

• plastic wrap
• plasticizer,
• cytotoxicity,
• liver cells
• in vitro

詳細情報

• CRID: 1390290699799669760
• NII論文ID: 120006880210
• NII書誌ID: AA00508441
• ISSN: 0386300X
• DOI: 10.18926/amo/60371
• Web Site: https://ousar.lib.okayama-u.ac.jp/60371
• Web Site: https://search.jamas.or.jp/link/ui/2021209283
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • CiNii Articles
  • KAKEN