Discovery of anti-mucoviscous activity of rifampicin and its potential as a candidate anti-virulence agent against hypervirulent Klebsiella pneumoniae

• Namikawa, Hiroki

• Oinuma, Ken-Ichi

• Sakiyama, Arata

• Tsubouchi, Taishi

• Tahara, Yuhei O.

• Yamada, Koichi

• Niki, Mamiko

• Takemoto, Yasuhiko

• Miyata, Makoto

• Kaneko, Yukihiro

• Shuto, Taichi

• Kakeya, Hiroshi

Abstract

リファンピシンが粘液活性を減少させ、高病原性肺炎桿菌の病原性を低下させることを見出した。

A recent increase in the incidence of hypervirulent Klebsiella pneumoniae (hvKP) infections, especially those caused by a sublineage of the clonal group CG23 (CG23-I), is raising serious health concerns worldwide. The high virulence of hvKP is, at least in part, attributed to the overproduction of capsular polysaccharide (CPS), which is triggered by a positive regulator of capsular polysaccharide synthesis (cps) genes, named RmpA. Although extensive research has been conducted on the mechanisms ofhvKP virulence, no study has focused on the development of anti-virulence therapeutics....

Journal

• International Journal of Antimicrobial Agents

  International Journal of Antimicrobial Agents 54 (2), 167-175, 2019-08

  Elsevier

Keywords

• 高病原性肺炎桿菌
• 粘液活性
• リファンピシン
• hypervirulent klebsiella pneumoniae
• hypermucoviscous
• capsular polysaccharide
• rifampicin
• anti-mucoviscous
• antivirulence agent

Details

• CRID: 1050567175362767488
• NII Article ID: 120006882174
• NII Book ID: AA11530817
• ISSN: 09248579
• DOI: 10.1016/j.ijantimicag.2019.05.018
• Web Site: https://dlisv03.media.osaka-cu.ac.jp/il/meta_pub/G0000438repository_09248579-54-2-167
• Web Site: https://api.elsevier.com/content/article/PII:S0924857919301359?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0924857919301359?httpAccept=text/plain
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN