軽度血管内皮機能異常者における湿熱処理玄米米粉米菓単回摂取による血流依存性血管拡張反応の変化  [in Japanese] Effects of Single-intake of Rice Cracker Prepared from Heat-moisture-treated Brown Rice Flour on Vasodilator Response in Adults with Mild Endothelial Dysfunction  [in Japanese]

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Abstract

動脈硬化症を予防しうる食品の出現が期待されている.動脈硬化の早期発見・予防に血流依存性血管拡張反応(Flow-mediated dilation, FMD)検査があり,フェルラ酸を含む食事性ポリフェノール類によるFMD値の改善効果が報告されている.高アミロース米"越のかおり"の湿熱処理(0.4MPa・144℃・10分間)玄米米粉米菓(60gに総ポリフェノール量48mg・総フェルラ酸量24.6mg含有)を,FMD軽度異常者6名に単回摂取していただき,摂取前・摂取1時間後・摂取2時間後のFMD値を経時的に測定するオープン試験を実施した.FMD測定値は,摂取前(3.05 ± 0.77%)から摂取1時間後に最大値(4.23 ± 1.07%)になり,2時間後には減弱(2.98 ± 1.34%)したが,Dunnett多重検定法で比較すると統計的な差異を示さなかった(P = 0.137). 1時間後のFMD変化量(⊿1.18 ± 0.99%)は増加傾向(P=0.053)を示した.本試験の結果は,新しい健康機能を付与した米菓開発の可能性を示唆するものと考えられた.Atherosclerosis (which leads to cardiovascular diseases) can be regulated by diet. Vascular endothelial function, which is influenced by oxidative stress, is a potent surrogate marker of atherosclerosis and cardiovascular mortality. Dietary polyphenols involving ferulic acid are known to improve flow-mediated dilation (FMD) values. We performed an open label intervention study, investing time-course effects of single-intake of rice cracker (60g, containing 48 mg of total polyphenols and 24.6 mg of ferulic acid equivalent) prepared from heat-moisture-treated (0.4MPa/144˚C • 10min) brown rice flour (high-amylose rice, Koshinokaori) on FMD response at baseline, 1 hour and 2 hours after intake in adults with mild endothelial dysfunction (n = 6). Observed FMD values at 1 hour after intake were found to reach maximum (4.23 ± 1.07%) being not significant from the baseline (3.05 ± 0.77%, P = 0.137) by Dunnett's multiple comparison test, but, the delta-FMD showed a tendency toward increase (Δ1.18 ± 0.99%. P = 0.053). These results are considered to suggest the possibility for developing rice crackers with a new health function.

Journal

  • 新潟医学会雑誌 = Niigata medical journal

    新潟医学会雑誌 = Niigata medical journal 133(9・10), 329-337, 2019-09

    新潟医学会

Codes

  • NII Article ID (NAID)
    120006885522
  • NII NACSIS-CAT ID (NCID)
    AN00182415
  • Text Lang
    JPN
  • Article Type
    departmental bulletin paper
  • ISSN
    0029-0440
  • NDL Article ID
    030603508
  • NDL Call No.
    Z19-254
  • Data Source
    NDL  IR 
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