A Trial of Analysis Method for Insulin Secretion Response to Carbohydrate Loading

• Bando, Hiroshi

• Ebe, Koji

• Hashimoto, Mayumi

• Bando, Masahiro

• Muneta, Tetsuo

抄録

Authors et al. have continued diabetic practice and research for long, and started Low Carbohydrate Diet (LCD) first in Japan. We developed social LCD movement by Japanese LCD Promotion Association (JLCDPA), and proposed petite-, standard-, super LCDs with carbohydrate 40%, 26%, 12%, respectively. Methods included 9 healthy medical staffs and two exams of 75g Oral Glucose Tolerance Test (OGTT) and Meal Tolerance Test (MTT). MTT means super-LCD breakfast with carbohydrate 6g. Results showed that blood glucose / immunoreactive insulin (IRI) at 0-30 min on average changed 88.0-130.6 mg/dL/5.1-46.5 μU/mL for GTT, and 90.1-86.3 mg/dL/4.8-12.5 μU/mL for MTT. IRI responses in GTT and MTT were calculated by 3 methods, which are i) increment (delta), ii) Area Under the Curves (AUC), iii) Multiple (times) of basal value. Both data from GTT and MTT showed significant correlation in i) and ii) (p<0.05), but not significant in iii) (p=0.07, n=9). These results suggested that insulin secretion in MTT would be enough and relatively excessive for 6g of carbohydrate, leading to relatively decreased glucose at 30 min. Current analyses methods will become some reference for future development of diabetic research.

収録刊行物

• Edelweiss Journal of Biomedical Research and Review

  Edelweiss Journal of Biomedical Research and Review 2 (1), 20-23, 2020-07-09

  Edelweiss Publications

キーワード

• Area under the curves
• Glycemic index
• Meal tolerance test
• Low carbohydrate diet
• Japanese LCD promotion association

詳細情報

• CRID: 1050004225345644672
• NII論文ID: 120006885778
• ISSN: 26902613
• Web Site: http://repo.lib.tokushima-u.ac.jp/115273
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles