Clinical study on primary screening of oral cancer and precancerous lesions by oral cytology

• Sukegawa, Shintaro

• Ono, Sawako

• Nakano, Keisuke

• Takabatake, Kiyofumi

• Kawai, Hotaka

• Nagatsuka, Hitoshi

• Furuki, Yoshihiko

Abstract

Background This study was conducted to compare the histological diagnostic accuracy of conventional oral-based cytology and liquid-based cytology (LBC) methods. Methods Histological diagnoses of 251 cases were classified as negative (no malignancy lesion, inflammation, or mild/moderate dysplasia) and positive [severe dysplasia/carcinoma in situ (CIS) and squamous cell carcinoma (SCC)]. Cytological diagnoses were classified as negative for intraepithelial lesion or malignancy (NILM), oral low-grade squamous intraepithelial lesion (OLSIL), oral high-grade squamous intraepithelial lesion (OHSIL), or SCC. Cytological diagnostic results were compared with histology results. Results Of NILM cytology cases, the most frequent case was negative [LBCn = 50 (90.9%), conventionaln = 22 (95.7%)]. Among OLSIL cytodiagnoses, the most common was negative (LBCn = 34; 75.6%, conventionaln = 14; 70.0%). Among OHSIL cytodiagnoses (LBCn = 51, conventionaln = 23), SCC was the most frequent (LBCn = 31; 60.8%, conventionaln = 7; 30.4%). Negative cases were common (LBCn = 13; 25.5%, conventionaln = 14; 60.9%). Among SCC cytodiagnoses SCC was the most common (LBCn = 16; 88.9%, conventionaln = 14; 87.5%). Regarding the diagnostic results of cytology, assuming OHSIL and SCC as cytologically positive, the LBC method/conventional method showed a sensitivity of 79.4%/76.7%, specificity of 85.1%/69.2%, false-positive rate of 14.9%/30.7%, and false-negative rate of 20.6%/23.3%. Conclusions LBC method was superior to conventional cytodiagnosis methods. It was especially superior for OLSIL and OHSIL. Because of the false-positive and false-negative cytodiagnoses, it is necessary to make a comprehensive diagnosis considering the clinical findings.

Journal

• Diagnostic Pathology

  Diagnostic Pathology 15 (1), 107-, 2020-09-10

  BMC

Keywords

• Cytology
• Pathology
• Liquid-based cytology
• Screening
• Inflammation

Details

• CRID: 1050848650325459968
• NII Article ID: 120006890020
• ISSN: 17461596
• DOI: 10.1186/s13000-020-01027-6
• Web Site: https://ousar.lib.okayama-u.ac.jp/60768
• Web Site: https://link.springer.com/content/pdf/10.1186/s13000-020-01027-6.pdf
• Web Site: https://link.springer.com/article/10.1186/s13000-020-01027-6/fulltext.html
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN